DOI: 10.1016/j.cell.2016.10.031 year: 2017 study: UCLA-ASD title: Histone Acetylome-wide Association Study of Autism Spectrum Disorder. grants: R01MH094714 authors: Sun W, Poschmann J, Cruz-Herrera Del Rosario R, Parikshak NN, Hajan HS, Kumar V, Ramasamy R, Belgard TG, Elanggovan B, Wong CCY, Mill J, Geschwind DH, Prabhakar S journal: Cell abstract: The association of histone modification changes with autism spectrum disorder (ASD) has not been systematically examined. We conducted a histone acetylome-wide association study (HAWAS) by performing H3K27ac chromatin immunoprecipitation sequencing (ChIP-seq) on 257 postmortem samples from ASD and matched control brains. Despite etiological heterogeneity, ≥68% of syndromic and idiopathic ASD cases shared a common acetylome signature at >5,000 cis-regulatory elements in prefrontal and temporal pubmedId: 27863250 entity_name: Sun Cell 2017 (Pubmed ID 27863250)
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