DOI: 10.1038/nature20612 year: 2017 study: UCLA-ASD title: Genome-wide changes in lncRNA, splicing, and regional gene expression patterns in autism. grants: R01MH094714 authors: Parikshak NN, Swarup V, Belgard TG, Irimia M, Ramaswami G, Gandal MJ, Hartl C, Leppa V, Ubieta LdlT, Huang J, Lowe JK, Blencowe BJ, Horvath S, Geschwind DH journal: Nature abstract: Autism spectrum disorder (ASD) involves substantial genetic contributions. These contributions are profoundly heterogeneous but may converge on common pathways that are not yet well understood. Here, through post-mortem genome-wide transcriptome analysis of the largest cohort of samples analysed so far, to our knowledge, we interrogate the noncoding transcriptome, alternative splicing, and upstream molecular regulators to broaden our understanding of molecular convergence in ASD. Our analysis re pubmedId: 27919067 entity_name: Parikshak Nature 2017 (Pubmed ID 27919067)
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