url: https://www.jax.org/strain/035872 grant: U54AG054349 program: MODEL-AD summary: BIN1 is an important regulator of endocytosis and membrane dynamics, in addition to others. Neuronal BIN1 localizes to pre-synaptic termini where it functions in excitatory synaptic transmission via regulation of neurotransmitter vesicle dynamics. In humans, the 19 exon gene produces multiple isoforms with 7 brain specific isoforms. toolType: Mouse Model modelType: Late Onset Alzheimer's disease contributor: Grant MacGregor strainDetails: [View](https://www.jax.org/strain/035872) targetedGenes: Bin1 backgroundStrain: B6(SJL) mouseModelReport: [View](https://www.synapse.org/#!Synapse:syn25474068)