url: https://www.jax.org/strain/035316 grant: U54AG054349 program: MODEL-AD species: Mouse summary: ABCA7 is a member of the conserved superfamily of ATP-binding cassette (ABC) transporters. These multiple-pass transmembrane proteins transfer molecules across membranes in an ATP-dependent manner. ABCA7 participates in the efflux of cholesterol and phospholipids in different cell types. ABCA7 has been proposed to function in phagocytic clearance of APP Aβ oligomers in mouse brains and a deficiency in ABCA7 reduces phagocytosis in macrophages. toolType: Mouse Model modelType: Late Onset Alzheimer's disease contributor: Grant MacGregor strainDetails: [View](https://www.jax.org/strain/035316) targetedGenes: Abca7 backgroundStrain: C57BL/6J mouseModelReport: [View](https://www.synapse.org/#!Synapse:syn25474077)