url: https://www.jax.org/strain/035871 grant: U54AG054349 program: MODEL-AD species: Mouse summary: To create the Abi3S209F allele, CRISPR/Cas9 endonuclease-mediated genome editing of Abi3 was used to introduce a S212F mutation. This mutant allele models a SNP (rs616338) found in human ABI3 that encodes a missense mutation associated with increased risk of sporadic Alzheimer's disease. The mechanism of action of ABI3 is not yet fully understood. It appears to function in regulation of actin cytoskeletal dynamics, in a manner distinct from its related family members ABI1 and ABI2. toolType: Mouse Model modelType: Late Onset Alzheimer's disease contributor: Grant MacGregor strainDetails: [View](https://www.jax.org/strain/035871) targetedGenes: Abi3 backgroundStrain: C57BL/6J mouseModelReport: [View](https://www.synapse.org/#!Synapse:syn25474072)