url: https://www.jax.org/strain/035873 grant: U54AG054349 program: MODEL-AD species: Mouse summary: Spi1 encodes PU.1, an ETS-family transcription factor whose function is required for haematopoiesis, including microglial proliferation and activation associated with Alzheimer's Disease (AD) and other neurodegenerative conditions involving an inflammatory response. toolType: Mouse model modelType: Late Onset Alzheimer's Disease contributor: Grant MacGregor strainDetails: [View](https://www.jax.org/strain/035873) targetedGenes: Spi1 backgroundStrain: C57BL/6J mouseModelReport: [View](https://www.synapse.org/#!Synapse:syn25570580)