Dear All, I was looking into the two files reporting the metadata information, namely MSSM_human_individual.csv (syn51942196) and MSBB_individual_metadata.csv (syn6101474). My understanding is that the individual ID in the first file are a subset of the one in the second file, but I see that some values do not match (e.g., mismatching CERAD scores and some missing Braak scores). Is there a particular explanation I am missing? Moreover, in the file MSSM_human_individual (syn51942196) the field _diagnosis_ always reports Alzheimer disease, but if I cross-check this information with the CDR score in MSBB_individual_metadata (syn6101474) the classification seems to not add up in most cases. Am I again missing something here? I understood from previous discussion that it is better to rely on the CDR scale as it is rather than forcing a binary condition (AD vs Control), but would I be right to interpret this _diagnosis_ column as the patient's condition? If so, how would you explain the discrepancy with the values of the other metrics? As I am now working with the RNAseq data in syn7416949, shall I rely on the metadata in syn6101474? Thanks a lot for the clarification, Warm regards, Tamara.