I'm trying to determine if any of the RNAseq data in syn3157268 is from patients with familial AD. Can anyone help?

Created by Thomas LaRocca tlarocca
Hi Mariet, That makes sense. I wondered about the several subjects in their early ~60s, but I guess even that is relatively late. Thanks for the help! -Tom
Hi Thomas, The AD subjects all have late-onset AD and as such it is highly unlikely that they have mutations in APP, PSEN1 or PSEN2 that cause the familial form of the disease that affects patients in mid-life. That being said, they may not all have been screened for these. Mariet
Thanks for the quick response! I should have been a bit clearer: I was wondering if any of the subjects had mutations in Presenilin or APP genes. Is that information known/available?
The subjects included in this study are unrelated, and were not selected for or against based on a family history of AD.
Hi Thomas, @mxa24 - can you answer his question? Thanks! Ben

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