In the Mayo cohort, there are 41 samples described as having 'pathological diagnosis of pathologic aging' (syn7344223). I was wondering how this diagnosis was made, via imaging or post-mortem? If the latter, what thresholds of plaque and tau levels did they need to reach? Is there any consensus over whether these samples are likely to be resilient despite pathology _or_ whether they are the beginning stages of AD and would likely get symptoms if they had lived longer?