@AMPADDataReleaseUpdates The following data is now available. Study links are to the new [AMP-AD Knowledge Portal interface](https://www.synapse.org/#!Synapse:syn2580853/discussion/threadId=6335) ###Human [The ROSMAP study](https://adknowledgeportal.synapse.org/#/Explore/Studies?Study=syn3219045) * This study contains data generated from subjects participating in the Religious Orders Study (ROS) and Memory and Aging Project (MAP). These are longitudinal clinical-pathologic cohort studies of aging and AD run from Rush University. Previously released from these studies is GWAS, WGS, RNAseq on bulk and single nuclei from the dorsolateral prefrontal cortex, microglia RNAseq, array mRNA and miRNA expression, epigenetics, and metabolomics. * This release adds: * RNAseq from 13 samples of Microglia single cells isolated from the dorsolateral prefrontal cortex from 13 individuals with mild cognitive impairment and Alzheimer?s disease. * This release modifies: * Single nucleus RNAseq entities and file handles were renamed so that the entity name and file handle matches for each file. * 24 single nucleus RNAseq files were submitted in duplicate. The duplicate files were moved to a Deprecated data folder. * Eight duplicate specimenID records were removed from the biospecimen metadata file and scRNAseq assay metadata file. In both metadata files, the contents of the two records were condensed to retain all available metadata. [The UPP study](https://adknowledgeportal.synapse.org/#/Explore/Studies?Study=syn21411742) * This study contains data from brain tissue obtained from the autopsy collections of the University of Pennsylvania School of Medicine Brain Bank. Included is label free proteomics generated from the dorsolateral prefrontal cortex from 354 individuals with no cognitive impairment, Alzheimer?s and asymptomatic Alzheimer?s disease. [The MayoRNAseq study]() * This study contains data from brain tissue from individuals with neuropathological diagnosis of Alzheimer?s disease, progressive supranuclear palsy, pathologic aging, or elderly controls without neurodegenerative diseases obtained from the Banner Sun Health Research Institute and the Mayo Clinic Brain Bank. Previously released from this study is RNAseq on bulk tissue from the temporal cortex and cerebellum, proteomics from the temporal cortex and GWAS and whole genome sequencing * This release adds quality control assessment of the whole genome sequencing data. [The MC-CAA study](https://adknowledgeportal.synapse.org/#/Explore/Studies?Study=syn9779506) * This is two studies focused on cerebral amyloid angiopathy (CAA), utilizing post-mortem tissue samples from individuals neuropathologically diagnosed with Alzheimer?s disease. Previously released is RNAseq on bulk tissue from the temporal cortex from ?study 2? * This release adds: * Raw and normalized gene counts from the cerebellum from ?study 1? . Raw data for study 1 will be provided at an upcoming data release. * Also provided is GWAS plink files for individuals in study 1 * The metadata files for this study have been updated