If for a row in dosage file (for example, syn5879827), it likes: rs+number T C 1.1 1.2 1.3 1.4 ....
Then these values 1.1, 1.2, and so on, are calculated as follows:
0 * T/T + 1 * T/C + 2 * C/C
Do I understand this correctly? By the way, what do these 2 base symbols T C mean exactly?
Thanks.
Created by xinxingwu Hi, thanks for your kind reply. Thanks for the useful information. Understood. Yes, the dosage is the expected number of "B" alleles, where in your example C is the "B" allele and T is the "A" allele. Here T and C are the reference strand nucleotide bases variants at the SNP location. Nucleotide bases for DNA can be adenine (A), cytosine (C), guanine (G), and thymine (T).