DOI: 10.1016/j.stemcr.2020.12.019 year: 2021 study: iPSCNeuroDiff title: Cell-to-Cell Adhesion and Neurogenesis in Human Cortical Development: A Study Comparing 2D Monolayers with 3D Organoid Cultures. grants: U01MH103365 authors: Scuderi S, Altobelli GG, Cimini V, Coppola G, Vaccarino FM journal: Stem cell reports abstract: Organoids (ORGs) are increasingly used as models of cerebral cortical development. Here, we compared transcriptome and cellular phenotypes between telencephalic ORGs and monolayers (MONs) generated in parallel from three biologically distinct induced pluripotent stem cell (iPSC) lines. Multiple readouts revealed increased proliferation in MONs, which was caused by increased integrin signaling. MONs also exhibited altered radial glia (RG) polarity and suppression of Notch signaling, as well as im pubmedId: 33513360 entity_name: Scuderi Stem cell reports 2021 (Pubmed ID 33513360)
Drop files to upload
Scuderi Stem cell reports 2021 (Pubmed ID 33513360) page is loading…