DOI: 10.1126/science.aad6469 year: 2018 study: BrainGVEX UCLA-ASD title: Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap. grants: U01MH103340 R01MH110920 R01MH094714 authors: Gandal MJ, Haney JR, Parikshak NN, Leppa V, Ramaswami G, Hartl C, Schork AJ, Appadurai V, Buil A, Werge TM, Liu C, White KP, Horvath S, Geschwind DH journal: Science (New York N.Y.) abstract: The predisposition to neuropsychiatric disease involves a complex, polygenic, and pleiotropic genetic architecture. However, little is known about how genetic variants impart brain dysfunction or pathology. We used transcriptomic profiling as a quantitative readout of molecular brain-based phenotypes across five major psychiatric disorders-autism, schizophrenia, bipolar disorder, depression, and alcoholism-compared with matched controls. We identified patterns of shared and distinct gene-express pubmedId: 29439242 entity_name: Gandal Science (New York N.Y.) 2018 (Pubmed ID 29439242)
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