DOI: 10.1126/science.aat6720 year: 2019 study: Capstone Collection iPSC title: Transcriptome and epigenome landscape of human cortical development modeled in organoids. grants: U01MH103340 P50MH106934 UO1MH103339 U01MH103346 R21MH103877 U01MH103392 U01MH103392 U01MH103365 R01MH094714 U01MH103339 U01MH103365 authors: Amiri A, Coppola G, Scuderi S, Wu F, Roychowdhury T, Liu F, Pochareddy S, Shin Y, Safi A, Song L, Zhu Y, Sousa AMM, Gerstein M, Crawford GE, Sestan N, Abyzov A, Vaccarino FM journal: Science (New York N.Y.) abstract: Genes implicated in neuropsychiatric disorders are active in human fetal brain, yet difficult to study in a longitudinal fashion. We demonstrate that organoids from human pluripotent cells model cerebral cortical development on the molecular level before 16 weeks postconception. A multiomics analysis revealed differentially active genes and enhancers, with the greatest changes occurring at the transition from stem cells to progenitors. Networks of converging gene and enhancer modules were assemb pubmedId: 30545853 entity_name: Amiri Science (New York N.Y.) 2019 (Pubmed ID 30545853)
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