DOI: 10.1126/science.aat8077 year: 2019 study: NHP-Macaque Capstone Collection title: Spatiotemporal transcriptomic divergence across human and macaque brain development. grants: U01MH103339 U01MH103340 P50MH106934 UO1MH103339 U01MH103346 R21MH103877 U01MH103392 U01MH103392 U01MH103365 R01MH094714 U01MH103339 authors: Zhu Y, Sousa AMM, Gao T, Skarica M, Li M, Santpere G, Esteller-Cucala P, Juan D, Ferrández-Peral L, Gulden FO, Yang M, Miller DJ, Marques-Bonet T, Imamura Kawasawa Y, Zhao H, Sestan N journal: Science (New York N.Y.) abstract: Human nervous system development is an intricate and protracted process that requires precise spatiotemporal transcriptional regulation. We generated tissue-level and single-cell transcriptomic data from up to 16 brain regions covering prenatal and postnatal rhesus macaque development. Integrative analysis with complementary human data revealed that global intraspecies (ontogenetic) and interspecies (phylogenetic) regional transcriptomic differences exhibit concerted cup-shaped patterns, with a pubmedId: 30545855 entity_name: Zhu Science (New York N.Y.) 2019 (Pubmed ID 30545855)
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