url: https://www.jax.org/strain/036535 grant: U54AG054345 program: MODEL-AD summary: The human F352V variant is associated with decreased late-onset Alzheimer's disease (LOAD)-associated amyloid plaque burden in patients who also carry the APOE4 polymorphism. modelType: Late Onset Alzheimer's disease contributor: Mike Sasner strainDetails: [View](https://www.jax.org/strain/036535) targetedGenes: KLOTHO backgroundStrain: C57BL/6J