url: https://www.jax.org/strain/036534 grant: U54AG054345 program: MODEL-AD summary: Kl-F/C mice carry the S370C point mutation in exon 2 of the Klotho gene, homologous to the human late-onset Alzheimer's disease "risk" configuration of p.F352 and p.C370. modelType: Late Onset Alzheimer's disease contributor: Mike Sasner strainDetails: [View](https://www.jax.org/strain/036534) targetedGenes: KLOTHO backgroundStrain: C57BL/6J