url: https://www.jax.org/strain/035794 grant: U54AG054345 program: MODEL-AD summary: MAPT(H1.0*N279K)-GR mice express the human MAPT (H1 haplotype) with the pathogenic N279K mutation, MAPT-AS1 transcripts and the typical MAPT protein isoforms. modelType: Late Onset Alzheimer's disease contributor: Mike Sasner strainDetails: [Name](https://www.jax.org/strain/035794) targetedGenes: MAPT backgroundStrain: C57BL/6J alzforumInformation: [View](https://www.alzforum.org/research-models/mapth10n279k-gr)