url: https://www.jax.org/strain/033781 grant: U54AG054345 program: MODEL-AD summary: This Trem2*R47HHSS strain has a mutant mouse Trem2 gene consisting of an R47H point mutation, along with 2 other silent mutations and a "humanized splice site" in exon 2. Unlike mice carrying the Trem2em1Adiuj allele (JAX #027918) which expresses a novel truncated splice variant due to a cryptic splice acceptor site in exon 2, these Trem2em4Adiuj mice do not have a cryptic splice acceptor site and show normal express levels of Trem2. modelType: Late Onset Alzheimer's disease contributor: Mike Sasner strainDetails: [View](https://www.jax.org/strain/033781) targetedGenes: TREM2 backgroundStrain: C57BL/6J