url: https://www.jax.org/strain/034036 grant: U54AG054349 program: MODEL-AD summary: The Trem2*R47HNSS mutation is one of the strongest genetic risk factors for late-onset Alzheimer's disease (LOAD). To create the Trem2*R47H<NSS> allele, CRISPR/Cas9 endonuclease-mediated genome editing of Trem2 was used to introduce a R47H mutation. R47H is homologous to the human R47H SNP shown to correlate with increased risk of LOAD. RNA-seq analysis of hippocampus and cortex indicates that the Trem2*R47H<NSS> allele is expressed at a level similar to the wild-type Trem2 allele modelType: Late Onset Alzheimer's disease contributor: Grant MacGregor availableData: Trem2R47H_NSS strainDetails: [View](https://www.jax.org/strain/034036) targetedGenes: TREM2 backgroundStrain: C57BL/6J mouseModelReport: [View](https://www.synapse.org/#!Synapse:syn25474065)