Dear participants, To comply with [ISBI format](https://biomedicalimaging.org/2022/guidelines-author-4-page/), you need to include a statement on ethical compliance in a separate section entitled ?Compliance with Ethical Standards?. Here is the text you need to include in this section: This research study was conducted retrospectively using de-identified human subject data made available in open access after Institutional Review Board approval at the University of Minnesota and the Cleveland Clinic. Ethical approval for subsequent data use such as this was not required. Good luck, Knight challenge organizers.