We organize the Brain Tumor Sequence Registration Challenge (BraTS-Reg) in conjunction with MICCAI2022. The BraTS-Reg challenge focuses on estimating correspondences between baseline pre-operative and follow up scans of the same patient diagnosed with a brain glioma and intends to establish a benchmark environment for deformable registration algorithms. The training and validation data has been released and leaderboard is also live! More details about the challenge can be found at: https://www.med.upenn.edu/cbica/brats-reg-challenge/