Granzyme K+ CD8 T cells form a core population in inflamed human tissue

syn29837062

Using data from the AMP-RA_scImmuneRepertoireSeq dataset, synovial tissue and synovial fluid CD8+ T cells were found to be predominated by a population of effector CD8+ T cells characterized by high expression of granzyme K and low expression of granzyme B and perforin as described in Science Translational Medicine https://doi.org/10.1126/scitranslmed.abo0686.
Created By Mette Peters Mette

assay: ['single cell Immune Repertoire sequencing', 'scRNA-seq']
program: AMP-RA/SLE
project: RA_PhaseII
ARKRelease: 1.0
datasetType: Publication
specimenType: PBMC synovium
datasetDescription: syn47265559
acknowledgmentStatement: syn26710600/wiki/619685

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Granzyme K+ CD8 T cells form a core population in inflamed human tissue

syn29837062

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