Type: GCD status: Curated disease: Cancer species: Homo sapiens citation: Multiclass cancer diagnosis using tumor gene expression signatures. Ramaswamy S, Tamayo P, Rifkin R, Mukherjee S, Yeang CH, Angelo M, Ladd C, Reich M, Latuilippe E, Mesirov JP, Poggio T, Gerald W, Loda M, Lander ES, Golub TR PNAS. 2001. 98(26):15149-54. Signatures of mutation and selection in the cancer genome. Bignell GR, Greenman CD, Davies H, Butler AP, Edkins S, Andrews JM, Buck G, Chen L, Beare D, Latimer C, Widaa S, Hinton J, Fahey C, Fu B, Swamy S, Dalgliesh GL, Teh BT, Deloukas P, Yang F, Campbell PJ, Futreal PA, Stratton MR. Nature. 2010 Feb 18;463(7283):893-8. pubmedId: 20164919 SampleType: Cell Line numSamples: 749 tissueType: Multiple Institution: Sanger releaseDate: 1236643200000 Investigator: Stratton Internal_Name: Sanger_Cell_Lines release_notes: Sanger Cell Line Project The Sanger and the Broad have worked together to provide molecular profiles on the most commonly used cancer cell lines. The purpose of this project is to provide genetic insights into variation in cellular drug response phenotypes. Unrestricted Data ***************** Expression profiles: Profiles were generated by Todd Golub at the Broad using the Affymetrix U1332.0 Plus array. Replicate expression data are available for 66 of the 732 cell lines profiled. Drug response phenotypes: These IC50s are provided through the Sanger site and are updated periodically. The version of the phenotypes included in this packet was downloaded on 1/4/2011. It is possible that additional data are available on the Sanger website (http://www.sanger.ac.uk/genetics/CGP/ or ftp://ftp.sanger.ac.uk/pub/CGP/). Restricted Access Data ********************** SNP genotypes and CNV data are available for these cell lines, but are not included in this packet. These data can be found on the Sanger website (http://www.sanger.ac.uk/genetics/CGP/) locationStatus: available syn3275758 syn88646 syn4723 syn4727