phase: I grants: R01MH105472 tissue: striatum methods: syn5584630 species: Mouse dataTypes: Chromatin Activity studyType: Individual studyDescription: The MouseHAL study is assessing whether differential gene expression in mouse striatum subsequent to haloperidol treatment (a drug used to treat schizophrenia) is related to changes in chromatin accessibility. Chromatin accessibility is one of the regulatory genomic elements thought to play an important role in gene expression. The data will provide insight into how variation in non-coding regulatory factors in the brain contributes to schizophrenia pathogenesis. nucleicAcidSource: bulk nuclei contributingInstitution: Duke University syn5613808