phase: I grants: U01MH103365 methods: syn17023612 syn12043331 syn4590912 syn16805359 species: Human dataTypes: Gene Expression Chromatin Activity studyType: Individual studyDescription: The iPSC study is comparing transcriptomic and epigenomic landscapes in cortical organoids – collections of differentiated cells derived from human induced pluripotent stem cells (iPSCs) thought to recapitulate early cortical development – and postmortem human brain tissue. The aim is to characterize dynamic gene regulatory activity across human embryonic brain development and to validate the suitability of iPSC-derived organoids as a model system for studying neurodevelopmental genomics. nucleicAcidSource: bulk cell bulk nuclei single cell numberOfIndividuals: 11 contributingInstitution: Yale University syn5613806 syn17081608