Dear Thomas,
I hope this message finds you well.
I am interested in the ?Normalized protein data for brain region? in dataset syn51150434 and would like to explore the associations between some genetic variants and brain protein abundance based on this dataset. However, I have a few questions regarding the data preprocessing:
1.Have sample outliers been removed?
2.Has the data been regressed on batch, MS mode, age at death, PMI, and clinical diagnosis?
3.Has the data been Z-score transformed?
4.Does the dataset only include the most abundant isoform for each protein?
Your assistance in providing this information would be greatly appreciated. Thank you for your time and help.
Best regards, Yijun