phase: I grants: R21MH102791 tissue: dorsolateral prefrontal cortex methods: syn6173961 syn5843155 species: Human dataTypes: Genomic Variants Chromatin Activity diagnosis: Schizophrenia studyType: Individual studyDescription: Using whole-genome bisulfite sequencing (WGBS), the LIBD-WGBS study is characterizing cell type-specific DNA methylation in postmortem human brain samples across neocortical development. WGBS data are integrated with transcriptomic data from the same samples to explore the epigenetic effects of methylation on gene expression, and to gain insight into the etiology of neurodevelopmental diseases such as schizophrenia. nucleicAcidSource: sorted nuclei numberOfIndividuals: 44 contributingInstitution: Lieber Institute for Brain Development syn5842548