Hello, I am specifically working with GENIE patients with Glioblastoma (GBM) that can be primary (first occurrence) or recurrent (oddly, labeled as Metastatic under "Sample.Type", which is incorrect terminology. Although that is not the focus of this question). There are 3 MSK panels included in GENIE v10-- MSK 341, 410, and 468. Each successive panel is an update of the prior. There are many GBM patients whose samples were assayed by 2 of the 3 panels, and based on the "Age at which sequencing was reported" column, it seems that panel 341 was always used before 410 and 468, and 410 before 468. However, both samples are reported as primary tumors. It is highly unlikely that so many MSK patients would have multiple distinct primary GBM, and the time frames suggest that the latter sample/panel result is probably a recurrent GBM, not a primary tumor. However, I don't know how to confirm this. Alternatively, part of the original sample was preserved and re-assayed months or years later by the newer panel. That would explain why the tumor is still reported as primary and the age at sequencing is later in the newer panels. In that case, why is the sample identifier different than the "earlier" sample? Can you please advise? Thank you!