The Target ALS Global Natural History Study (GNHS), part of the ALS Global Research Initiative (AGRI), is an international, multicenter observational study designed to generate a comprehensive, longitudinal multi-omic dataset to support ALS biomarker discovery and disease-mechanism research. The study aims to recruit 800 ALS patients and 200 healthy controls across 18 international clinical sites. Created By Ram Ayyala ram.ayyala
url: https://targetals.org/ title: Target ALS Dataset source: Target ALS creator: Target ALS disease: ALS Control species: Homo sapiens dataType: genomics keywords: whole genome sequencing genomicVariants haplotype calls qc reports variant_calls studyType: Natural History Study collection: Target ALS contributor: Target ALS curationLevel: Raw libraryLayout: single-end portalRelease: 2026.1 diseaseSubtype: Definite_ALS Possible_ALS Probable_ALS Probable_ALS_Lab_Supported bulbar_onset limb_onset biospecimenType: blood csf spinal_cord individualCount: 86 libraryStrategy: WGS processingLevel: raw processed participant_count: 86 acknowledgementStatement: syn64892175/wiki/639413